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Front Matter -- Copyright Page -- Dedication -- Foreword -- Preface -- Acknowledgements -- Contributors -- Introduction -- Why and How to Shift the Paradigm -- Refinement on the Way Towards Replacement: Are We Doing What We Can? /Kathrin Herrmann -- How to Evaluate the Science of Non-human Animal Use in Biomedical Research and Testing: A Proposed Format for Debate /Ray Greek and Lisa A. Kramer -- How Can the Final Goal of Completely Replacing Animal Procedures Successfully Be Achieved? /Christiane Baumgartl-Simons and Christiane Hohensee -- Disease Prevention with a Plant-based Lifestyle /Sabina V. Vyas -- Politics and Legislation of Animal Experimentation -- Political Campaigning: Where Scientific and Ethical Arguments Meet Public Policy /Emily McIvor -- Rethinking the 3Rs: From Whitewashing to Rights /Charlotte E. Blattner -- Contesting Animal Experiments through Ethics and Epistemology: In Defense of a Political Critique of Animal Experimentation /Arianna Ferrari -- Openness in Animal Experimentation -- The Moral Status of Animal Research Subjects in Industry: A Stakeholder Analysis /Sarah Kenehan -- Increasing the Transparency of Animal Experimentation: An Australian Perspective /Monika Merkes and Rob Buttrose -- Wasted Money in United States Biomedical and Agricultural Animal Research /Jim Keen -- The Ethics and Philosophy of Animal Experimentation -- Ethics, Efficacy, and Decision-making in Animal Research /Lawrence A. Hansen and Kori Ann Kosberg -- Beyond Plausibility Checks: A Case for Moral Doubt in Review Processes of Animal Experimentation /Mara-Daria Cojocaru and Philipp von Gall -- Human Wrongs in Animal Research: A Focus on Moral Injury and Reification /Jane Johnson and Anna Smajdor -- Effectiveness of the Animal Model -- Critically Evaluating Animal Research /Andrew Knight -- Extrapolation of Animal Research Data to Humans: An Analysis of the Evidence /Rebecca Ram -- Is Animal-based Biomedical Research Being Used in Its Original Context? /Constança Carvalho , Daniel Alves , Andrew Knight and Luis Vicente -- The Scientific Problems with Using Non-Human Animals to Predict Human Response to Drugs and Disease /Ray Greek and Lisa A. Kramer -- Replacing Animal Tests to Improve Safety for Humans /Kathy Archibald , Robert Coleman and Tamara Drake -- Genetic Modification of Animals: Scientific and Ethical Issues /Jarrod Bailey -- Animal Research for Alzheimer Disease: Failures of Science and Ethics /John J. Pippin , Sarah E. Cavanaugh and Francesca Pistollato -- Behavioral Research on Captive Animals: Scientific and Ethical Concerns /Kimberley Jayne and Adam See -- Animal-free Education and Training -- Modernizing Biomedical Training: Replacing Live Animal Laboratories with Human Simulation /John Pawlowski , David Feinstein , Marie L. Crandall and Shalin Gala -- Humane Education: The Tool for Scientific Revolution in Brazil /Vanessa Carli Bones , Rita de Cássia Maria Garcia , Gutemberg Gomes Alves , Rita Leal Paixão , Alexandro Aluísio Rocha , Karynn Capilé and Róber Bachinski -- The Paradigm Shift: Advanced Animal-free Approaches -- Recent Developments in Alternatives to Animal Testing /Katy Taylor. Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science
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